Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.
نویسندگان
چکیده
Mice deficient in phox (gp91(phox-/-)) or NOS2 (NOS2(-/-)) were infected with the agent of human granulocytic ehrlichiosis (HGE) to evaluate the importance of these pathways in the eradication of HGE bacteria. NOS2(-/-) mice had delayed clearance of the HGE agent in comparison to control or gp91(phox-/-) mice, suggesting that reactive nitrogen intermediates play a role in the early control of HGE.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 68 7 شماره
صفحات -
تاریخ انتشار 2000